Portal de investigación
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study
Fecha de publicación:
Autores de FUNDANET
Autores ajenos a FUNDANET
- Moleón, J
- Robles-Vera, I
- Miñano, S
- de la Visitación, N
- Barranco, AM
- Martín-Morales, N
- O'Valle, F
- Mayo-Martínez, L
- García, A
- Toral, M
- Jiménez, R
- Romero, M
- Duarte, J
Unidades de investigación
Abstract
This study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SLE) mice were treated with resistant-starch (RS) or inulin-type fructans (ITF). In addition, inoculation of fecal microbiota from these experimental groups to recipient normotensive female C57Bl/6J germ-free (GF) mice was per-formed. Both fiber treatments, especially RS, prevented the development of hypertension, renal injury, improved the aortic relaxation induced by acetylcholine, and the vascular oxidative stress. RS and ITF treatments increased the proportion of acetate-and butyrate-producing bacteria, respectively, improved colonic inflammation and integrity, endotoxemia, and decreased helper T (Th)17 proportion in mesenteric lymph nodes (MLNs), blood, and aorta in SLE mice. However, disease activity (splenomegaly and anti-ds-DNA) was unaffected by both fibers. T cell priming and Th17 differentiation in MLNs and increased Th17 infiltration was linked to aortic endothelial dysfunction and hypertension after inoculation of fecal microbiota from SLE mice to GF mice, without changes in proteinuria and autoimmunity. All these effects were lower in GF mice after fecal inoculation from fiber-treated SLE mice. In conclusion, these findings support that fiber consumption prevented the development of hypertension by rebalancing of dysfunctional gut-immune system-vascular wall axis in SLE.
Datos de la publicación
- ISSN/ISSNe:
- 1949-0976, 1949-0984
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 37615336
- Factor de Impacto:
- 3,075 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Gut Microbes Landes Bioscience
Citas Recibidas en Web of Science: 16
Citas Recibidas en Scopus: 17
Documentos
- No hay documentos
Filiaciones
Keywords
- Hypertension; endothelial dysfunction; fibers; gut dysbiosis; immune system; systemic lupus erythematosus
Financiación
Cita
SíArticle2023Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study10.1080/19490976.2023.2247053MoleónJ;GONZÁLEZ CORREAC;Robles VeraI;MiñanoS;de la VisitaciónN;BarrancoAM;Martín MoralesN et al.37615336.2-s2.0-85168593163.001055102000001.
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study -2023 -Article -Gut Microbes -19490976 -Moleón,J.;González Correa,C.;Robles Vera,I.;Miñano,S.;de la Visitación,N.;Barranco,A.M.;Martín Morales,N. et al -
Moleón J,González C,Robles I,Miñano S,de la Visitación N,Barranco AM,Martín N,O'Valle F,Mayo L,García A,Toral M,Jiménez R,Romero M,Duarte J. Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study. Gut Microbes. 2023 15 2. IF:12,200. (1).
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study/.Article/.2023./.17-16/.Moleón,J; González Correa,C; Robles Vera,I; Miñano,S; de la Visitación,N; Barranco,AM; Martín Morales,N et al/.
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study/.Moleón,J;González Correa,C;Robles Vera,I;Miñano,S;de la Visitación,N;Barranco,AM;Martín Morales,N et al/.10.1080/19490976.2023.2247053/.(2)/.17/.Gut Microbes/.Año2023/.
Moleón J; González Correa C; Robles Vera I; Miñano S; de la Visitación N; Barranco AM; Martín Morales N; O'Valle F; Mayo Martínez L; García A; Toral M; Jiménez R; Romero M; Duarte J. Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study. Gut Microbes. 2023. 15(2):FI: 12,200 (Q1) (D1)
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study Gut Microbes 10.1080/19490976.2023.2247053Gut Microbes RtyyhujMoleón,J;González Correa,C;Robles Vera,I;Miñano,S;de la Visitación,N;Barranco,AM;Martín Morales,N et al
