Portal de investigación
Ether lipids and sphingolipids drive sex-specific human aging dynamics.
Autores de FUNDANET
Autores ajenos a FUNDANET
- Fernàndez-Bernal A
- Mota-Martorell N
- Martín-Garí M
- Obis È
- Juanes A
- Ayala V
- Mayneris-Perxachs J
- Ramos R
- Pineda V
- Garre-Olmo J
- Portero-Otín M
- Fernández-Real JM
- Puig J
- Jové M
- Pamplona R
Unidades de investigación
Abstract
Aging is a dynamic process characterized by complex molecular changes, including shifts in lipid metabolism. To systematically define lipidome dynamics with age and identify sex-specific lipidomic signatures, we performed targeted lipidomic profiling of plasma samples from 1030 adults aged 50-98 years, analyzing 543 lipid species across all lipid classes using high-throughput mass spectrometry and assessing the circulating fatty acid composition by gas chromatography. Our results reveal age-related lipidomic shifts, with ceramides and ether-linked phospholipids most affected. We identified three aging crests (55-60, 65-70, 75-80 years), with the 65-70 years crest dominant in men and the 75-80 years crest in women. Lipid enrichment analyses highlight acylcarnitines, sphingolipids and ether-linked phospholipids as key contributors, with functional indices indicating compositional shifts in lipid species. These findings suggest an impairment of lipid functional categories, including loss of dynamic properties, alterations in bioenergetics, antioxidant defense, cellular identity, and signaling platforms. This study underscores the non-linear nature of lipid metabolism in aging and provides a foundation for identifying biomarkers and interventions to promote healthy aging.
Copyright © 2025 The Authors. Published by Elsevier B.V. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 2213-2317, 2213-2317
- Tipo:
- Article
- Páginas:
- 103779-103779
- PubMed:
- 40706291
Redox biology Elsevier BV
Documentos
- No hay documentos
Filiaciones
Keywords
- Aging crests; Aging dynamics; Ether-linked phospholipids; Lipid metabolism; Metabolic adaptation; Sex-specific lipidomics; Sphingolipids
Cita
Desconocido2025Article2025p. 103779-103779Ether lipids and sphingolipids drive sex-specific human aging dynamics.10.1016/j.redox.2025.103779SOLJ;Fernàndez BernalA;Mota MartorellN;Martín GaríM;ObisÈ;JuanesA;AyalaV et al.40706291.2-s2.0-105011265306.001540543300001.
Ether lipids and sphingolipids drive sex-specific human aging dynamics. -Article -Redox Biology -22132317 -Sol,J.;Fernàndez Bernal,A.;Mota Martorell,N.;Martín Garí,M.;Obis,È.;Juanes,A.;Ayala,V. et al -
Sol J,Fernàndez A,Mota N,Martín M,Obis È,Juanes A,Ayala V,Mayneris J,Ramos R,Pineda V,Garre J,Portero M,Fernández JM,Puig J,Jové M,Pamplona R. Ether lipids and sphingolipids drive sex-specific human aging dynamics. Redox Biol. 85p. 103779-103779.
Ether lipids and sphingolipids drive sex-specific human aging dynamics./.Article/.0-0/.Sol,J; Fernàndez Bernal,A; Mota Martorell,N; Martín Garí,M; Obis,È; Juanes,A; Ayala,V et al/.
Ether lipids and sphingolipids drive sex-specific human aging dynamics./.Sol,J;Fernàndez Bernal,A;Mota Martorell,N;Martín Garí,M;Obis,È;Juanes,A;Ayala,V et al/.10.1016/j.redox.2025.103779/.0/.Redox Biology/.
Sol J; Fernàndez Bernal A; Mota Martorell N; Martín Garí M; Obis È; Juanes A; Ayala V; Mayneris Perxachs J; Ramos R; Pineda V; Garre Olmo J; Portero Otín M; Fernández Real JM; Puig J; Jové M; Pamplona R. Ether lipids and sphingolipids drive sex-specific human aging dynamics. Redox Biology. 85103779-103779.
Ether lipids and sphingolipids drive sex-specific human aging dynamics. Redox Biology 10.1016/j.redox.2025.103779Redox Biol. RtyyhujSol,J;Fernàndez Bernal,A;Mota Martorell,N;Martín Garí,M;Obis,È;Juanes,A;Ayala,V et al
